Pharmacological Inhibition of CCR2 Signaling Exacerbates Exercise-Induced Inflammation Independently of Neutrophil Infiltration and Oxidative Stress

Although exercise-induced humoral factors known as exerkines benefit systemic health, the role of most has not been investigated. Monocyte chemoattractant protein-1 (MCP-1) is a representative chemokine whose circulating concentrations increase after exercise, and it one exerkines. MCP-1 ligand for CC receptor 2 (CCR2), which expressed on monocytes, macrophages, muscle cells. However, there no information CCR2 signaling in exercise. Therefore, to investigate research question, we administrated antagonist or PBS mice inhibit before Our results showed that inhibition promoted macrophage infiltration inflammation 24 h exercise muscle. also exacerbated immediately neutrophil oxidative stress had contribution by inhibition. kidney, liver, adipose tissues. To summarize, pharmacological independently stress.